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CD8+ T Cell Responses to Plasmodium and Intracellular Parasites

[ Vol. 9 , Issue. 3 ]


Nicolas Villarino and Nathan W. Schmidt   Pages 169 - 178 ( 10 )


Parasitic protozoa are major threats to human health affecting millions of people around the world. Control of these infections by the host immune system relies on a myriad of immunological mechanisms that includes both humoral and cellular immunity. CD8+ T cells contribute to the control of these parasitic infections in both animals and humans. Here, we will focus on the CD8+ T cell response against a subset of these protozoa: Plasmodium, Toxoplasma gondii, Leishmania and Trypanosoma cruzi, with an emphasis on experimental rodent systems. It is evident a complex interaction occurs between CD8+ T cells and the invading protozoa. A detailed understanding of how CD8+ T cells mediate protection should provide the basis for the development of effective vaccines that prevent and control infections by these parasites.


CD8+ T cell, immunity, Leishmania, malaria, Plasmodium, protozoa, Toxoplasma, Trypanosoma.


Department of Microbiology, M409 Walters Life Sciences, 1414 W. Cumberland Ave., Knoxville, TN 37996, USA.

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