Mahirah Mahmud, Mek K. Jing and Adi Idris Pages 27 - 34 ( 8 )
The cells of the innate immune system continually undergo surveillance of the extracellular milieu to serve as the first line of defense against invading microbial pathogens. As a result, these innate immune cells have evolved receptors to sense microbial motifs and danger signals. The inflammasome is an important component of the innate immune system’s “arsenal” against invading microbes such as viruses and bacteria and acts as a homeostatic checkpoint to regulate inflammation. Inflammasomes are cytosolic multi-protein complexes that activate caspase 1 and 11, which result in the production of pro-inflammatory interleukin (IL)-1β and IL-18, and cell death. Several studies have uncovered the mechanisms of inflammasome activation in response to various stimuli ranging from environmental stimulants to microbial components. This mini-review summarizes the current developments and updates in the mechanism of action of inflammasomes.
DAMP, inflammasome, interleukin 1, immunity, NOD-like receptors, PAMP.
PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link Gadong, Brunei Darussalam.