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Mechanisms of Inflammatory Atherosclerosis in Rheumatoid Arthritis

[ Vol. 12 , Issue. 1 ]

Author(s):

Zoltan Szekanecz, Gyorgy Kerekes, Zsofia Kardos, Zsuzsa Barath and Laszlo Tamasi   Pages 35 - 46 ( 12 )

Abstract:


Cardiovascular disease dependent on inflammatory accelerated atherosclerosis leads to increased mortality in rheumatoid arthritis (RA). In addition to traditional, Framingham risk factors, several immuno-inflammatory cells, mediators and molecules may link atherosclerosis to arthritis. Among immune cells, primarily TH1 cells, as well as endothelial cells play a crucial role in synovial and vascular inflammation. Various cell surface molecules, such as adhesion receptors, CD40-CD40 ligand or members of the RANK-RANK ligand-osteoprotegerin system, as well as soluble pro-inflammatory cytokines, chemokines, autoantibodies and proteases have been implicated in RA and vascular damage. The early assessment of atherosclerosis and early intervention would decrease cardiovascular risk in RA.

Keywords:

Atherosclerosis, biologics, cardiovascular disease, chemokines, cytokines, DMARDs, endothelial cells, proteases, RANK ligand, rheumatoid arthritis.

Affiliation:

Department of Rheumatology, Institute of Medicine, University of Debrecen, Faculty of Medicine Nagyerdei str 98, 4032, Debrecen, Hungary.



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