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Orchestrating HIV Neutralization by Secondary Immune Response- Mediated Induction of RF Antibodies

[ Vol. 12 , Issue. 2 ]

Author(s):

Konstantin V. Suslov   Pages 118 - 124 ( 7 )

Abstract:


Antibody-dependent enhancement of infection is among the main challenges for HIV vaccines. Neutralization-enhancing RF antibodies (NeRFa) arising against immune complexes during secondary immune response not only enhance the action of neutralizing antibodies but also make infectionenhancing antibodies neutralizing in a sensitized virus. NeRFa represent the oldest type of immune response since it protects a fetus with unformed immune system from maternally acquired infections. Vaccination with HIV gp120 glycoprotein each 3 weeks may be a strategy to induce NeRFa both in prophylactic and therapeutic immunizations. Twenty-fold reduction in amount of protein for secondary immunization is important for an optimal induction of NeRFa. Auto-vaccination via transient immune suppression with dexamethasone might be a promising way to induce NeRFa in HIV-infected patients.

Keywords:

Rheumatoid factor, immune complexes, neutralization-enhancing RF antibodies, NeRFa, HIV, repeated immunization, HIV vaccine, dexamethasone.

Affiliation:

Institute of Immunology, 24/2 Kashirskoe Sh., Moscow 115 478

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