Ramazan Rezaei, Saeed Aslani, Mahdi Marashi, Farhad Rezaei and Ehsan Sharif-Paghaleh* Pages 40 - 49 ( 10 )
Background: Vitamin D has mainly been described in the literature beyond its skeletal functions, including an influence on the immune responses against infections. Observational and interventional studies have represented evidence that Vitamin D deficiency may cause increased risk of seasonal influenza and pulmonary tract infection.
Methods: A structured search of EMBASE, Medline, and Web of Science databases was fulfilled to extract all eligible articles published prior to September 2017.
Results: In this review, our goal is to define the possible mechanisms that link influenza-mediated immune responses to Vitamin D. Herein, we first briefly describe the role of Vitamin D in the immune responses and then elucidate three immunological processes that connect Vitamin D to influenza infection. Finally, we describe randomized controlled trials and observational studies exploring the effect of Vitamin D supplementation on seasonal influenza infections and vaccinations.
Conclusion: Our literature review suggests that treatment of influenza-infected individuals with Vitamin D supplements or cathelicidin-derived agents may provide appreciable protection against natural influenza infection. Moreover, Vitamin D given at appropriate doses may facilitate protection against seasonal flu.
Vitamin D, influenza virus, infection, immune response, infection, immunomodulatory effect.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran